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BIOCHEMISTRY AND BIOLOGICAL SCIENCE

2018
M.S. Verma, M.J. Fink, G. L. Salmon, N. Fornelos, T.E. Ohara, S.H. Ryu, H. Vlamakis, R.J. Xavier, T.S. Stappenbeck, and G. M. Whitesides. 2018. “A Common Mechanism Links Activities of Butyrate in the Colon.” ACS Chemical Biology, 13, Pp. 1291-1298. PDF Supplemental
1306
J. M. Fox, M. Zhao, M.J. Fink, K. Kang, and G. M. Whitesides. 2018. “The Molecular Origin of Enthalpy/Entropy Compensation in Biomolecular Recognition.” Annual Review of Biophysics, 47, Pp. 223-250. PDF
1305
2017
J. M. Fox, K. Kang, M. Sastry, W. Sherman, B. Sankaran, P. H. Zwart, and G. M. Whitesides. 2017. “Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase.” Angew. Chem., 56, Pp. 3833-3837. PDF Supplemental
1288
2016
K. Kang, J-M. Choi, J. M. Fox, P. W. Snyder, D. T. Moustakas, and G. M. Whitesides. 2016. “Acetylation of Surface Lysine Groups of a Protein Alters the Organization and Composition of its Crystal Contacts.” J. Phys. Chem. B, 120, Pp. 6461-6468.Abstract
9.5.2, 9.5.4, 9.5.5
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S. G. Turney, M. Ahmed, I. Chandrasekar, R. B. Wysolmerski, Z. M. Goeckeler, R. M. Rioux, G. M. Whitesides, and P. C. Bridgman. 2016. “Nerve Growth Factor Stimulates Axon Outgrowth through Negative Regulation of Growth Cone Actomyosin Restraint of Microtubule Advance.” Molecular Biology of the Cell, 27, Pp. 500-517. PDF
1267
2015
J. M. Fox, K. Kang, W. Sherman, A. Heroux, M. Sastry, M. Baghbanzadeh, M. R. Lockett, and G. M. Whitesides. 2015. “Interactions between Hofmeister Anions and the Binding Pocket of a Protein.” J. Amer. Chem. Soc., 137, Pp. 3859-3866. PDF Supplemental
1251
2014
M. Kim, D. Kang, T. Wu, N. Tabatabaei, R. W. Carruth, R. V. Martinez, G. M. Whitesides, Y. Nakajima, and G. J. Tearney. 2014. “Miniature Objective Lens with Variable Focus for Confocal Endomicroscopy.” Biomedical Optics Express, 5, Pp. 4250-4361. PDF Supplemental
1236
2013
M. R. Lockett, H. Lange, B. Breiten, A. Heroux, W. Sherman, D. Rappoport, P. O. Yau, P. W. Snyder, and G. M. Whitesides. 2013. “The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand.” Angew. Chemie., 125, Pp. 7868-7871. PDF
1182
P. W. Snyder, M. R. Lockett, D. T. Moustakas, and G. M. Whitesides. 2013. “Is it the Shape of the Cavity, or the Shape of the Water in the Cavity?” European Physical Journal Special Topics, 223, Pp. 853-891. PDF
1185
B. Breiten, M. R. Lockett, W. Sherman, S. Fujita, M. Al-Sayah, H. Lange, C. M. Bowers, A. Heroux, G. Krilov, and G. M. Whitesides. 2013. “Water Networks Contribute to Enthalpy/Enthropy Compensation in Protein-Ligand Binding.” J. Amer. Chem. Soc., 135, Pp. 15579-15584. PDF
1195
2012
E. T. Mack, P. W. Snyder, R. Perez-Castillejos, B. Bilgicer, D. T. Moustakas, M. J. Butte, and G. M. Whitesides. 2012. “Dependence of Avidity on Linker Length for a Bivalent Ligand-Bivalent Receptor Model System.” J. Amer. Chem. Soc., 134, Pp. 333-345.Abstract
PMCID:PMC3272676
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1138
B. F. Shaw, G. F. Schneider, and G. M. Whitesides. 2012. “Effect of Surfactant Hydrophobicty on the Pathway for Unfolding of Ubiquitin.” J. Amer. Chem. Soc., 134, Pp. 18739-18745.Abstract
PMCID: PMC3518387
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1167
N. D. Shapiro, S. Soh, K. A. Mirica, and G. M. Whitesides. 2012. “Magnetic Levitation as a Platform for Competitive Protein-Ligand Binding Assays.” Analytical Chemistry, 84, Pp. 6166-6172.Abstract
PMCID: PMC3433162
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1162
K. A. Mirica, M. R. Lockett, P. W. Snyder, N. D. Shapiro, E. T. Mack, S. Nam, and G. M. Whitesides. 2012. “Selective Precipitation and Purification of Monovalent Proteins Using Oligovalent Ligands and Ammonium Sulfate.” Bioconjugate Chem., 23, Pp. 293-299.Abstract
PMCID: PMC3288307
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1142
2011
B. F. Shaw, G. F. Schneider, H. Arthanari, M. Narovlyansky, D. T. Moustakas, A. Durazo, G. Wagner, and G. M. Whitesides. 2011. “Complexes of Native Ubiquitin and Dodecyl Sulfate Illustrate the Nature of Hydrophobic and Electrostatic Interactions in the Binding of Proteins and Surfactants.” J. Amer. Chem. Soc., 133, Pp. 17681-17695.Abstract
KEYWORDS:PMCID:PMC3209763
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1136
A. Lee, S. K. Y. Tang, C. R. Mace, and G. M. Whitesides. 2011. “Denturation of Proteins by SDS and by Tetraalkylammonium Dodecyl Sulfates.” Langmuir, 27, Pp. 11560-11574.Abstract
PMCID:3172379
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1131
J. Mecinovic, P. W. Snyder, K. A. Mirica, S. Bai, E. T. Mack, R. L. Kwant, D. T. Moustakas, A. Herous, and G. M. Whitesides. 2011. “Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the "Hydrophobic Wall" of Carbonic Anhydrase.” J. Amer. Chem. Soc., 133, Pp. 14017-14026.Abstract
PMCID:3171206
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1127
A. Lee, K. A. Mirica, and G. M. Whitesides. 2011. “The Influence of Fluorocarbon and Hydrocarbon Acyl Groups at the Surface of Bovine Carbonic Anhydrase II on the Kinetics of Denaturation by Sodium Dodecyl Sulfate.” J. Phys. Chem. B, 115, Pp. 1199-1210.Abstract
PMCID:3034637
PDF Supplemental
1108
P. W. Snyder, J. Mecinovic, D. T. Moustakas, S. W. Thomas, M. Harder, E. T. Mack, M. R. Lockett, A. Heroux, W. Sherman, and G. M. Whitesides. 2011. “Mechanism of the Hydrophobic Effect in the Biomolecular Recognition of Arylsulfonamides by Carbonic Anhydrase.” Proc. Natl. Acad. Sci. USA, 108, Pp. 17889-17894.Abstract
KEYWORDS: carbonic anhydrase; aromatic sulfonamides; hydrophobic effect; molecular recognitionPMC3207675
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1134
P. J. Bracher, P. W. Snyder, B. R. Bohall, and G. M. Whitesides. 2011. “The Relative Rates of Thiol-Thioester Exchange and Hydrolysis for Alkyl and Aryl Thioalkanoates in Water.” Origins Life Evol. Biosph., 41, Pp. 399-412. PDF
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