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Carbonic Anhydrase and Protein-Ligand Binding

1996
Q. Wu, J. Gao, D. Joseph-McCarthy, G. B. Sigal, J. E. Bruce, G. M. Whitesides, and R. D. Smith. 1996. “Carbonic Anhydrase-Inhibitor Binding: From Solution to the Gas Phase.” J. Am. Chem. Soc., 119, Pp. 1157-1158. PDF
525
J. Gao, M. Mammen, and G. M. Whitesides. 1996. “Evaluating Electrostatic Contributions to Binding with the Use of Protein Charge Ladders.” Science, 272, Pp. 535-537. PDF
492
J. Gao, X. Cheng, R. Chen, G. B. Sigal, J. E. Bruce, B. L. Schwartz, S. A. Hofstadler, G. A. Anderson, R. D. Smith, and G. M. Whitesides. 1996. “Screening Derivatized Peptide Libraries for Tight Binding Inhibitors to Carbonic Anhydrase II by Electrospray Ionization-Mass Spectrometry.” Journal of Medicinal Chemistry, 39, Pp. 1949-1955. PDF
488
G. B. Sigal, C. Bamdad, A. Barberis, J. Strominger, and G. M. Whitesides. 1996. “A Self-Assembled Monolayer for the Binding and Study of Histidine-Tagged Proteins by Surface Plasmon Resonance.” Analytical Chemistry, 68, Pp. 490-497. PDF
481
1995
Y-H. Chu, L. Z. Avila, J. Gao, and G. M. Whitesides. 1995. “Affinity Capillary Electrophoresis.” Acc. Chem. Res., 28, Pp. 461-468. PDF
461
M. Mrksich, J. R. Grunwell, and G. M. Whitesides. 1995. “Bio-Specific Adsorption of Carbonic Anhydrase to Self-Assembled Monolayers of Alkanethiolates that Present Benzenesulfonamide Groups on Gold.” J. Am. Chem. Soc., 117, Pp. 12009-12010. PDF
470
M. Mammen, F. A. Gomez, and G. M. Whitesides. 1995. “Determination of the Binding of Ligands Containing the N-2,4-Dinitrophenyl Group to Bivalent Monoclonal Rat Anti-DNP Antibody Using Affinity Capillary Electrophoresis.” Anal. Chem., 67, Pp. 3526-3535. PDF
467
J. Gao, S. Qiao, and G. M. Whitesides. 1995. “Increasing Binding Constants of Ligands to Proteins by Using 'Greasy Tails'.” J. Med. Chem., 38, Pp. 2292-2301. PDF
457
D. N. Chin and G. M. Whitesides. 1995. “Molecular Dynamics Simulations of H2NSO2C6H4CONH(Gly)3Bn Bound to the Active Site of Human Carbonic Anhydrase II.” J. Am. Chem. Soc., 117, Pp. 6153-6164. PDF
449
P.A. Boriack, D.W. Christianson, J. E. Kingery-Wood, and G. M. Whitesides. 1995. “Secondary Interactions Significantly Removed from the Sulfonamide Binding Pocket of Carbonic Anhydrase II Influence Binding Constants.” J. Med. Chem., 38, Pp. 2286-2291. PDF
459
X. Cheng, R. Chen, J. E. Bruce, B. L. Schwartz, G. A. Anderson, S. A. Hofstadler, D. C. Gale, R. D. Smith, J. Gao, G. B. Sigal, M. Mammen, and G. M. Whitesides. 1995. “Using Electrospray Ionization FTICR Mass Spectrometry to Study Competitive Binding of Inhibitors to Carbonic Anhydrase.” J. Am. Chem. Soc., 117, Pp. 8859-8860. PDF
460
1994
F. A. Gomez, J. K. Chen, A. Tanaka, S. L. Schreiber, and G. M. Whitesides. 1994. “Affinity Capillary Electrophoresis: Insights into the Binding of SH3 Domains by Peptides Derived from an SH3-Binding Protein.” J. Org. Chem., 59, Pp. 2885-2886. PDF
410
F. A. Gomez, L. Z. Avila, Y-H. Chu, and G. M. Whitesides. 1994. “Determination of Binding Constants of Ligands to Proteins by Affinity Capillary Electrophoresis: Compensation for Electroosmotic Flow.” Anal. Chem., 66, Pp. 1785-1791. PDF
409
A. Jain, G. M. Whitesides, R.S. Alexander, and D.W. Christianson. 1994. “Identification of Two Hydrophobic Patches in the Active Site Cavity of Human Carbonic Anhydrase II by Solution-Phase and Solid-State Studies and Their Use in the Development of Tight-Binding Inhibitors.” J. Med. Chem., 37, Pp. 2100-2105. PDF
399
A. Jain, S. G. Huang, and G. M. Whitesides. 1994. “Lack of Effect of the Length of Oligoglycine- and Oligo(ethylene glycol)- Derived para-Substituents on the Affinity of Benzenesulfonamides for Carbonic Anhydrase II in Solution.” J. Am. Chem. Soc., 116, Pp. 5057-5062. PDF
398
1993
Y-H. Chu, J. K. Chen, and G. M. Whitesides. 1993. “Affinity Electrophoresis in Multisectional Polyacrylamide Slab is a Useful and Convenient Technique for Measuring Binding Constants of Aryl Sulfonamides to Bovine Carbonic Anhydrase B.” Anal. Chem., 65, Pp. 1314-1322. PDF
376
L. Z. Avila, Y-H. Chu, E. C. Blossey, and G. M. Whitesides. 1993. “Use of Affinity Capillary Electrophoresis to Determine Kinetic and Equilibrium Constants for Binding of Arylsulfonamides to Bovine Carbonic Anhydrase.” J. Med. Chem., 36, Pp. 126-133. PDF
368
1989
A. Jain, E. M. Marzluff, J. R. Jacobsen, G. M. Whitesides, and J. J. Grabowski. 1989. “A New, General Method for the Determination of Binding Constants: Photoacoustic Titration of Dansylamide with Carbonic Anhydrase.” J. Chem. Soc. Chem. Comm., Pp. 1557-1559. PDF
266
1978
R. Horowitz and G. M. Whitesides. 1978. “Generalized Affinity Chromatography: Enzyme-Sulfonamide Conjugates Can Be Isolated by Adsorption on Immobilized Carbonic Anhydrase.” J. Am. Chem. Soc., 100, Pp. 4632-4633. PDF
96

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