J. M. Fox, K. Kang, M. Sastry, W. Sherman, B. Sankaran, P. H. Zwart, and G. M. Whitesides. 2017. “Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase.” Angew. Chem., 56, Pp. 3833-3837. PDF Supplemental

K. Kang, J-M. Choi, J. M. Fox, P. W. Snyder, D. T. Moustakas, and G. M. Whitesides. 2016. “Acetylation of Surface Lysine Groups of a Protein Alters the Organization and Composition of its Crystal Contacts.” J. Phys. Chem. B, 120, Pp. 6461-6468.Abstract PDF

J. M. Fox, K. Kang, W. Sherman, A. Heroux, M. Sastry, M. Baghbanzadeh, M. R. Lockett, and G. M. Whitesides. 2015. “Interactions between Hofmeister Anions and the Binding Pocket of a Protein.” J. Amer. Chem. Soc., 137, Pp. 3859-3866. PDF Supplemental

M. R. Lockett, H. Lange, B. Breiten, A. Heroux, W. Sherman, D. Rappoport, P. O. Yau, P. W. Snyder, and G. M. Whitesides. 2013. “The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand.” Angew. Chemie., 125, Pp. 7868-7871. PDF

P. W. Snyder, M. R. Lockett, D. T. Moustakas, and G. M. Whitesides. 2013. “Is it the Shape of the Cavity, or the Shape of the Water in the Cavity?” European Physical Journal Special Topics, 223, Pp. 853-891. PDF

B. Breiten, M. R. Lockett, W. Sherman, S. Fujita, M. Al-Sayah, H. Lange, C. M. Bowers, A. Heroux, G. Krilov, and G. M. Whitesides. 2013. “Water Networks Contribute to Enthalpy/Enthropy Compensation in Protein-Ligand Binding.” J. Amer. Chem. Soc., 135, Pp. 15579-15584. PDF

B. F. Shaw, G. F. Schneider, and G. M. Whitesides. 2012. “Effect of Surfactant Hydrophobicty on the Pathway for Unfolding of Ubiquitin.” J. Amer. Chem. Soc., 134, Pp. 18739-18745.Abstract PDF

K. A. Mirica, M. R. Lockett, P. W. Snyder, N. D. Shapiro, E. T. Mack, S. Nam, and G. M. Whitesides. 2012. “Selective Precipitation and Purification of Monovalent Proteins Using Oligovalent Ligands and Ammonium Sulfate.” Bioconjugate Chem., 23, Pp. 293-299.Abstract PDF Supplemental

B. F. Shaw, G. F. Schneider, H. Arthanari, M. Narovlyansky, D. T. Moustakas, A. Durazo, G. Wagner, and G. M. Whitesides. 2011. “Complexes of Native Ubiquitin and Dodecyl Sulfate Illustrate the Nature of Hydrophobic and Electrostatic Interactions in the Binding of Proteins and Surfactants.” J. Amer. Chem. Soc., 133, Pp. 17681-17695.Abstract PDF

J. Mecinovic, P. W. Snyder, K. A. Mirica, S. Bai, E. T. Mack, R. L. Kwant, D. T. Moustakas, A. Herous, and G. M. Whitesides. 2011. “Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the "Hydrophobic Wall" of Carbonic Anhydrase.” J. Amer. Chem. Soc., 133, Pp. 14017-14026.Abstract PDF Supplemental

A. Lee, K. A. Mirica, and G. M. Whitesides. 2011. “The Influence of Fluorocarbon and Hydrocarbon Acyl Groups at the Surface of Bovine Carbonic Anhydrase II on the Kinetics of Denaturation by Sodium Dodecyl Sulfate.” J. Phys. Chem. B, 115, Pp. 1199-1210.Abstract PDF Supplemental

P. W. Snyder, J. Mecinovic, D. T. Moustakas, S. W. Thomas, M. Harder, E. T. Mack, M. R. Lockett, A. Heroux, W. Sherman, and G. M. Whitesides. 2011. “Mechanism of the Hydrophobic Effect in the Biomolecular Recognition of Arylsulfonamides by Carbonic Anhydrase.” Proc. Natl. Acad. Sci. USA, 108, Pp. 17889-17894.Abstract PDF Supplemental

B. F. Shaw, H. Arthanari, A. Lee, A. Durazo, D.P Frueh, M. P. Pollastri, B. Bilgicer, S. P. Gygi, G. Wagner, and G. M. Whitesides. 2010. “Neutralizing Positive Charges at the Surface of a Protein Lowers its Rate of Amide Hydrogen Exchange without Altering its Structure or Increasing its Thermostability.” J. Amer. Chem. Soc., 132, Pp. 17411-17425.Abstract PDF Supplemental

G. M. Whitesides, P. W. Snyder, D. T. Moustakas, and K. A. Mirica. 2008. “Designing Ligands to Bind Tightly to Proteins.” In Physical Biology: From Atoms to Medicine, edited by A. H. Zewail, 9th ed., Pp. 189-215. London: Imperial College Press. PDF

V.M. Krishnamurthy, V. Semetey, P. J. Bracher, N. Shen, and G. M. Whitesides. 2007. “Dependence of Effective Molarity on Linker Length for an Intramolecular Protein-Ligand System.” J. Amer. Chem. Soc., 129, Pp. 1312-1320. 979.pdf

B. Bilgicer, D. T. Moustakas, and G. M. Whitesides. 2007. “A Synthetic Trivalent Hapten that Aggregates Anti-2, 4-DNP IgGs into Bicyclic Trimers.” J. Amer. Chem. Soc., 129, Pp. 3722-3728. 987.pdf

K. L. Gudiksen, I. Gitlin, and G. M. Whitesides. 2006. “Differentiation of Proteins based on Characteristic Patterns of Association and Denaturation in Solutions of Sodium Dodecyl Sulfate.” Proc. Natl. Acad. Sci. USA, 103, Pp. 7968-7972. PDF

I. Gitlin, K. L. Gudiksen, and G. M. Whitesides. 2006. “Effects of Surface Charge on Denaturation of Bovine Carbonic Anhydrase.” ChemBioChem, 7, Pp. 1241-1250. 962.pdf

V.M. Krishnamurthy, L. A. Estroff, and G. M. Whitesides. 2006. “Multivalency in Ligand Design.” In Fragment-based Approaches in Drug Discovery, edited by R. Mannhold, H. Kubinyi, and G. Folkers, 34: Pp. 11-53. Weinheim: WILEY-VCH Verlag GmbH & Co. 963.pdf

G. M. Whitesides and V.M. Krishnamurthy. 2005. “Designing Ligands to Bind Proteins.” Quarterly Reviews of Biophysics, 38, Pp. 385-395. PDF