Water in Biology

J. M. Fox, M. Zhao, M.J. Fink, K. Kang, and G. M. Whitesides. 2018. “The Molecular Origin of Enthalpy/Entropy Compensation in Biomolecular Recognition.” Annual Review of Biophysics, 47, Pp. 223-250. PDF
K. Kang, J-M. Choi, J. M. Fox, P. W. Snyder, D. T. Moustakas, and G. M. Whitesides. 2016. “Acetylation of Surface Lysine Groups of a Protein Alters the Organization and Composition of its Crystal Contacts.” J. Phys. Chem. B, 120, Pp. 6461-6468.Abstract
9.5.2, 9.5.4, 9.5.5
J. M. Fox, K. Kang, W. Sherman, A. Heroux, M. Sastry, M. Baghbanzadeh, M. R. Lockett, and G. M. Whitesides. 2015. “Interactions between Hofmeister Anions and the Binding Pocket of a Protein.” J. Amer. Chem. Soc., 137, Pp. 3859-3866. PDF Supplemental
P. W. Snyder, M. R. Lockett, D. T. Moustakas, and G. M. Whitesides. 2013. “Is it the Shape of the Cavity, or the Shape of the Water in the Cavity?” European Physical Journal Special Topics, 223, Pp. 853-891. PDF
B. Breiten, M. R. Lockett, W. Sherman, S. Fujita, M. Al-Sayah, H. Lange, C. M. Bowers, A. Heroux, G. Krilov, and G. M. Whitesides. 2013. “Water Networks Contribute to Enthalpy/Enthropy Compensation in Protein-Ligand Binding.” J. Amer. Chem. Soc., 135, Pp. 15579-15584. PDF
K. A. Mirica, M. R. Lockett, P. W. Snyder, N. D. Shapiro, E. T. Mack, S. Nam, and G. M. Whitesides. 2012. “Selective Precipitation and Purification of Monovalent Proteins Using Oligovalent Ligands and Ammonium Sulfate.” Bioconjugate Chem., 23, Pp. 293-299.Abstract
PMCID: PMC3288307
PDF Supplemental
P. W. Snyder, J. Mecinovic, D. T. Moustakas, S. W. Thomas, M. Harder, E. T. Mack, M. R. Lockett, A. Heroux, W. Sherman, and G. M. Whitesides. 2011. “Mechanism of the Hydrophobic Effect in the Biomolecular Recognition of Arylsulfonamides by Carbonic Anhydrase.” Proc. Natl. Acad. Sci. USA, 108, Pp. 17889-17894.Abstract
KEYWORDS: carbonic anhydrase; aromatic sulfonamides; hydrophobic effect; molecular recognitionPMC3207675
PDF Supplemental
G. M. Whitesides, P. W. Snyder, D. T. Moustakas, and K. A. Mirica. 2008. “Designing Ligands to Bind Tightly to Proteins.” In Physical Biology: From Atoms to Medicine, edited by A. H. Zewail, 9th ed., Pp. 189-215. London: Imperial College Press. PDF
G. M. Whitesides and V.M. Krishnamurthy. 2005. “Designing Ligands to Bind Proteins.” Quarterly Reviews of Biophysics, 38, Pp. 385-395. PDF
R. S. Kane, P. Deschatelets, and G. M. Whitesides. 2003. “Kosmotropes Form the Basis of Protein-Resistant Surfaces.” Langmuir, 19, Pp. 2388-2391. PDF
B. A. Grzybowski, A. V. Ishchenko, C. Y. Kim, G. Topalov, R. G. Chapman, D.W. Christianson, G. M. Whitesides, and E. I. Shakhnovich. 2002. “Combinatorial Computational Methods Give New Picomolar Ligands for a Known Enzyme.” Proc. Nat. Acad. Sci. USA, 99, Pp. 1270-1273. PDF
N. B. Bowden, M. Weck, I. S. Choi, and G. M. Whitesides. 2001. “Molecule-Mimetic Chemistry and Mesoscale Self-Assembly.” Acc. Chem. Res, 34, Pp. 231-238. PDF
E. Ostuni, R. G. Chapman, R. E. Holmlin, S. Takayama, and G. M. Whitesides. 2001. “A Survey of Structure-Property Relationships of Surfaces that Resist the Adsorption of Proteins.” Langmuir, 17, Pp. 5605-5620. PDF
G. M. Whitesides and H. A. Biebuyck. 1989. “The Physical-Organic Chemistry of Surfaces, and Its Relevance to Molecular Recognition.” In Molecular Recognition: Chemical and Biochemical Problems, edited by S. M. Roberts, Pp. 78, 270-285. Cambridge: Royal Society of Chemistry. PDF
G. M. Whitesides and A.H. Nishikawa. 1976. “Affinity Chromatography.” In Applications of Biochemical Systems in Organic Chemistry, edited by J.B. Jones, D. Perlman, and C.J. Sih, Pp. 929-968. New York: John Wiley & Sons. PDF