Water in Biology

2018
J. M. Fox, M. Zhao, M.J. Fink, K. Kang, and G. M. Whitesides. 2018. “The Molecular Origin of Enthalpy/Entropy Compensation in Biomolecular Recognition.” Annual Review of Biophysics, 47, Pp. 223-250. PDF
1305
2016
K. Kang, J-M. Choi, J. M. Fox, P. W. Snyder, D. T. Moustakas, and G. M. Whitesides. 2016. “Acetylation of Surface Lysine Groups of a Protein Alters the Organization and Composition of its Crystal Contacts.” J. Phys. Chem. B, 120, Pp. 6461-6468.Abstract
9.5.2, 9.5.4, 9.5.5
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1280
2015
J. M. Fox, K. Kang, W. Sherman, A. Heroux, M. Sastry, M. Baghbanzadeh, M. R. Lockett, and G. M. Whitesides. 2015. “Interactions between Hofmeister Anions and the Binding Pocket of a Protein.” J. Amer. Chem. Soc., 137, Pp. 3859-3866. PDF Supplemental
1251
2013
P. W. Snyder, M. R. Lockett, D. T. Moustakas, and G. M. Whitesides. 2013. “Is it the Shape of the Cavity, or the Shape of the Water in the Cavity?” European Physical Journal Special Topics, 223, Pp. 853-891. PDF
1185
B. Breiten, M. R. Lockett, W. Sherman, S. Fujita, M. Al-Sayah, H. Lange, C. M. Bowers, A. Heroux, G. Krilov, and G. M. Whitesides. 2013. “Water Networks Contribute to Enthalpy/Enthropy Compensation in Protein-Ligand Binding.” J. Amer. Chem. Soc., 135, Pp. 15579-15584. PDF
1195
2012
K. A. Mirica, M. R. Lockett, P. W. Snyder, N. D. Shapiro, E. T. Mack, S. Nam, and G. M. Whitesides. 2012. “Selective Precipitation and Purification of Monovalent Proteins Using Oligovalent Ligands and Ammonium Sulfate.” Bioconjugate Chem., 23, Pp. 293-299.Abstract
PMCID: PMC3288307
PDF Supplemental
1142
2011
P. W. Snyder, J. Mecinovic, D. T. Moustakas, S. W. Thomas, M. Harder, E. T. Mack, M. R. Lockett, A. Heroux, W. Sherman, and G. M. Whitesides. 2011. “Mechanism of the Hydrophobic Effect in the Biomolecular Recognition of Arylsulfonamides by Carbonic Anhydrase.” Proc. Natl. Acad. Sci. USA, 108, Pp. 17889-17894.Abstract
KEYWORDS: carbonic anhydrase; aromatic sulfonamides; hydrophobic effect; molecular recognitionPMC3207675
PDF Supplemental
1134
2008
G. M. Whitesides, P. W. Snyder, D. T. Moustakas, and K. A. Mirica. 2008. “Designing Ligands to Bind Tightly to Proteins.” In Physical Biology: From Atoms to Medicine, edited by A. H. Zewail, 9th ed., Pp. 189-215. London: Imperial College Press. PDF
1026
2005
G. M. Whitesides and V.M. Krishnamurthy. 2005. “Designing Ligands to Bind Proteins.” Quarterly Reviews of Biophysics, 38, Pp. 385-395. PDF
941
2003
R. S. Kane, P. Deschatelets, and G. M. Whitesides. 2003. “Kosmotropes Form the Basis of Protein-Resistant Surfaces.” Langmuir, 19, Pp. 2388-2391. PDF
830
2002
B. A. Grzybowski, A. V. Ishchenko, C. Y. Kim, G. Topalov, R. G. Chapman, D.W. Christianson, G. M. Whitesides, and E. I. Shakhnovich. 2002. “Combinatorial Computational Methods Give New Picomolar Ligands for a Known Enzyme.” Proc. Nat. Acad. Sci. USA, 99, Pp. 1270-1273. PDF
774
2001
N. B. Bowden, M. Weck, I. S. Choi, and G. M. Whitesides. 2001. “Molecule-Mimetic Chemistry and Mesoscale Self-Assembly.” Acc. Chem. Res, 34, Pp. 231-238. PDF
723
E. Ostuni, R. G. Chapman, R. E. Holmlin, S. Takayama, and G. M. Whitesides. 2001. “A Survey of Structure-Property Relationships of Surfaces that Resist the Adsorption of Proteins.” Langmuir, 17, Pp. 5605-5620. PDF
749
1989
G. M. Whitesides and H. A. Biebuyck. 1989. “The Physical-Organic Chemistry of Surfaces, and Its Relevance to Molecular Recognition.” In Molecular Recognition: Chemical and Biochemical Problems, edited by S. M. Roberts, Pp. 78, 270-285. Cambridge: Royal Society of Chemistry. PDF
267
1976
G. M. Whitesides and A.H. Nishikawa. 1976. “Affinity Chromatography.” In Applications of Biochemical Systems in Organic Chemistry, edited by J.B. Jones, D. Perlman, and C.J. Sih, Pp. 929-968. New York: John Wiley & Sons. PDF
82