Carbonic Anhydrase and Protein-Ligand Binding

2017
J. M. Fox, K. Kang, M. Sastry, W. Sherman, B. Sankaran, P. H. Zwart, and G. M. Whitesides. 2017. “Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase.” Angew. Chem., 56, Pp. 3833-3837. PDF Supplemental
1288
2013
M. R. Lockett, H. Lange, B. Breiten, A. Heroux, W. Sherman, D. Rappoport, P. O. Yau, P. W. Snyder, and G. M. Whitesides. 2013. “The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand.” Angew. Chemie., 125, Pp. 7868-7871. PDF
1182
B. Breiten, M. R. Lockett, W. Sherman, S. Fujita, M. Al-Sayah, H. Lange, C. M. Bowers, A. Heroux, G. Krilov, and G. M. Whitesides. 2013. “Water Networks Contribute to Enthalpy/Enthropy Compensation in Protein-Ligand Binding.” J. Amer. Chem. Soc., 135, Pp. 15579-15584. PDF
1195
2012
E. T. Mack, P. W. Snyder, R. Perez-Castillejos, B. Bilgicer, D. T. Moustakas, M. J. Butte, and G. M. Whitesides. 2012. “Dependence of Avidity on Linker Length for a Bivalent Ligand-Bivalent Receptor Model System.” J. Amer. Chem. Soc., 134, Pp. 333-345.Abstract
PMCID:PMC3272676
PDF Supplemental
1138
N. D. Shapiro, S. Soh, K. A. Mirica, and G. M. Whitesides. 2012. “Magnetic Levitation as a Platform for Competitive Protein-Ligand Binding Assays.” Analytical Chemistry, 84, Pp. 6166-6172.Abstract
PMCID: PMC3433162
PDF Supplemental
1162
K. A. Mirica, M. R. Lockett, P. W. Snyder, N. D. Shapiro, E. T. Mack, S. Nam, and G. M. Whitesides. 2012. “Selective Precipitation and Purification of Monovalent Proteins Using Oligovalent Ligands and Ammonium Sulfate.” Bioconjugate Chem., 23, Pp. 293-299.Abstract
PMCID: PMC3288307
PDF Supplemental
1142
2011
B. F. Shaw, G. F. Schneider, H. Arthanari, M. Narovlyansky, D. T. Moustakas, A. Durazo, G. Wagner, and G. M. Whitesides. 2011. “Complexes of Native Ubiquitin and Dodecyl Sulfate Illustrate the Nature of Hydrophobic and Electrostatic Interactions in the Binding of Proteins and Surfactants.” J. Amer. Chem. Soc., 133, Pp. 17681-17695.Abstract
KEYWORDS:PMCID:PMC3209763
PDF
1136
A. Lee, S. K. Y. Tang, C. R. Mace, and G. M. Whitesides. 2011. “Denturation of Proteins by SDS and by Tetraalkylammonium Dodecyl Sulfates.” Langmuir, 27, Pp. 11560-11574.Abstract
PMCID:3172379
PDF
1131
J. Mecinovic, P. W. Snyder, K. A. Mirica, S. Bai, E. T. Mack, R. L. Kwant, D. T. Moustakas, A. Herous, and G. M. Whitesides. 2011. “Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the "Hydrophobic Wall" of Carbonic Anhydrase.” J. Amer. Chem. Soc., 133, Pp. 14017-14026.Abstract
PMCID:3171206
PDF Supplemental
1127
A. Lee, K. A. Mirica, and G. M. Whitesides. 2011. “The Influence of Fluorocarbon and Hydrocarbon Acyl Groups at the Surface of Bovine Carbonic Anhydrase II on the Kinetics of Denaturation by Sodium Dodecyl Sulfate.” J. Phys. Chem. B, 115, Pp. 1199-1210.Abstract
PMCID:3034637
PDF Supplemental
1108
P. W. Snyder, J. Mecinovic, D. T. Moustakas, S. W. Thomas, M. Harder, E. T. Mack, M. R. Lockett, A. Heroux, W. Sherman, and G. M. Whitesides. 2011. “Mechanism of the Hydrophobic Effect in the Biomolecular Recognition of Arylsulfonamides by Carbonic Anhydrase.” Proc. Natl. Acad. Sci. USA, 108, Pp. 17889-17894.Abstract
KEYWORDS: carbonic anhydrase; aromatic sulfonamides; hydrophobic effect; molecular recognitionPMC3207675
PDF Supplemental
1134
E. T. Mack, P. W. Snyder, R. Perez-Castillejos, and G. M. Whitesides. 2011. “Using Covalent Dimers of Human Carbonic Anhydrase II to Model Bivalency in Immunoglubulins.” J. Amer. Chem. Soc., 133, Pp. 11701-11715.Abstract
PMC#PMC3145338
PDF Supplemental
1122
2008
V.M. Krishnamurthy, G. K. Kaufman, A. R. Urbach, I. Gitlin, K. L. Gudiksen, D. B. Weibel, and G. M. Whitesides. 2008. “Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein-Ligand Binding.” Chemical Reviews, 108, Pp. 946-1051. 1010.pdf
1010
G. M. Whitesides, P. W. Snyder, D. T. Moustakas, and K. A. Mirica. 2008. “Designing Ligands to Bind Tightly to Proteins.” In Physical Biology: From Atoms to Medicine, edited by A. H. Zewail, 9th ed., Pp. 189-215. London: Imperial College Press. PDF
1026
M. Mayer, V. Semetey, I. Gitlin, J. Yang, and G. M. Whitesides. 2008. “Using Ion Channel-Forming Peptides to Quantify Protein-Ligand Interactions.” J. Amer. Chem. Soc., 130, Pp. 1453-1465. 1007.pdf
1007
2007
V.M. Krishnamurthy, V. Semetey, P. J. Bracher, N. Shen, and G. M. Whitesides. 2007. “Dependence of Effective Molarity on Linker Length for an Intramolecular Protein-Ligand System.” J. Amer. Chem. Soc., 129, Pp. 1312-1320. 979.pdf
979
V.M. Krishnamurthy, B. R. Bohall, D. T. Moustakas, and G. M. Whitesides. 2007. “Thermodynamic Parameters for the Association of Fluorinated Benzenesulfonamides with Bovine Carbonic Anhydrase II.” Chemistry: An Asian Journal, 2, Pp. 94-105. 1005.pdf
1005
2006
I. Gitlin, K. L. Gudiksen, and G. M. Whitesides. 2006. “Effects of Surface Charge on Denaturation of Bovine Carbonic Anhydrase.” ChemBioChem, 7, Pp. 1241-1250. 962.pdf
962
K. L. Gudiksen, I. Gitlin, D. T. Moustakas, and G. M. Whitesides. 2006. “Increasing the Net Charge and Decreasing the Hydrophobicity of Bovine Carbonic Anhydrase Decreases the Rate of Denaturation with Sodium Dodecyl Sulfate.” Biophysical Journal, 91, Pp. 298-310. PDF
958
V.M. Krishnamurthy, B. R. Bohall, V. Semetey, and G. M. Whitesides. 2006. “The Paradoxical Themodynamic Basis for the Interaction of Ethylene Glycol, Glycine, and Sarcosine Chains with Bovine Carbonic Anhydrase II: An Unexpected Manifestation of Enthalpy/Entropy Compensation.” J. Am. Chem. Soc., 128, Pp. 5802-5812. PDF
950

Pages